Afoxolaner Safety For Dogs

In vitro membrane feeding assay data and in vivo pharmacokinetic studies in dogs established an afoxolaner blood concentration of 0 1 0 2 μg ml to be effective against.

Afoxolaner safety for dogs. These flea and tick preventives aren t exactly new. Unfortunately there is very little information on these drugs. After your dog takes the chew the drugs circulate in the blood and when a flea or tick bites your dog it s exposed to the chemical. Sometimes afoxolaner is used for the treatment of sarcoptic mange or demodectic mange.

Once a new kind of flea tick or heartworm medication is developed every veterinary pharmaceutical company tries to get on board as soon as they can and get their own product out on the market to make as much of a financial killing as possible before. The tablet should always be given as directed by your veterinarian. The drugs come in a soft chew that your dog can eat like a treat. Afoxolaner is an isoxazoline compound characterized by a good safety profile and extended effectiveness against fleas and ticks on dogs following a single oral administration.

Afoxolaner was recently approved in 2013 and most of the information available online points back to a study that was sponsored by merial who patented the drug. In dogs receiving doses of 120 and 200 mg kg bw vomiting was observed in the 24 hours following treatment. The majority of dogs have very few side effects from afoxolaner provided it is given according to label recommendations and at the prescribed interval. In comparison bravecto had a slightly higher overall rate of symptoms but did not cause seizures and it s also safe for pregnant breeding and lactating.

Akpool1021 are bravecto or nexgard safe. Some dogs also showed diarrhea. In a repeat dose toxicity study dogs were treated at 40 120 and 200 mg afoxolaner kg bw i e. These flea treatments are oral medications.

How the preventives work. These results are quite similar. Conclusion both drugs are relatively safe. 8x 20x and 35x the max.

Safety of afoxolaner and fluralaner. Even if your dog only spends a few minutes at a time outside chances are high that they will come into contact with pests. However nexgard had a lower overall prevalence of side effects but shows neurological effects that make it a poor choice for dogs with neurological issues. One of the most popular oral medications is nexgard the first chewable flea and tick treatment for dogs of course choosing any type of medicine for your four legged family member is not a decision that should be taken lightly particularly when it comes to pesticide.

The safety profile of afoxolaner a new isoxazoline molecule was evaluated following the regulatory requirements when administered six times orally in a soft chewable formulation at a dose of at least 1 3 or 5 the maximum exposure dose 6 3 mg kg in 8 week old beagle dogs. Recommended dose administered orally three times at eight week time intervals. Afoxolaner is used to treat and control flea and tick infestations in dogs.